A nucleoside reverse transcriptase inhibitor
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Zidovudine

Item No. 15492

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3’-azido-3’-deoxy-thymidine
CAS Number
30516-87-1
Synonyms
  • Azidothymidine
  • AZT
  • NSC 602670
  • ZDV
Molecular Formula
C10H13N5O4
Formula Weight
267.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
209, 266 nm
SMILES
CC1=CN([C@@H]2O[C@H](CO)[C@@H](N=[N+]=[N-])C2)C(NC1=O)=O
InChi Code
InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6?,7-,8-/m1/s1
InChi Key
HBOMLICNUCNMMY-SPDVFEMOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $36

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    100 mg

    $96

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    250 mg

    $135

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    1 g

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    Cayman Chemical
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    Product Description

    Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI).1 It is phosphorylated intracellularly to its active form zidovudine-5’-triphosphate by the successive actions of thymidine kinase, thymidylate kinase, and nucleoside diphosphate kinase.2 Zidovudine (0.01, 0.1, and 1 µM) reduces HIV-1 p24 antigen levels in the culture supernatant of HIV-1-infected isolated human peripheral blood monocytes.3 Formulations containing zidovudine have been used in the treatment of HIV infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cihlar, T., and Ray, A.S. Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine. Antiviral Res. 85(1), 39-58 (2010).

    2. Anderson, P.L., Nakuda, T.K., and Lichtenstein, K.A. The cellular pharmacology of nucleoside- and nucleotide-analogue reverse-transcriptase inhibitors and its relationship to clinical toxicities. Clin. Infect. Dis. 38(5), 743-753 (2004).

    3. Perno, C.-F., Yarchoan, R., Cooney, D.A., et al. Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2',3'-dideoxynucleosides. J. Exp. Med. 168(3), 1111-1125 (1988).