A nucleoside derivative and PARP inhibitor
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Isomer(s)
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5'-Azido-5'-deoxythymidine

Item No. 44620

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
19316-85-9
Synonyms
  • 5′-AZT
  • NSC 254064
Molecular Formula
C10H13N5O4
Formula Weight
267.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
O=C(C(C)=CN1[C@H]2C[C@@H]([C@H](O2)CN=[N+]=[N-])O)NC1=O
InChi Code
InChI=1S/C10H13N5O4/c1-5-4-15(10(18)13-9(5)17)8-2-6(16)7(19-8)3-12-14-11/h4,6-8,16H,2-3H2,1H3,(H,13,17,18)/t6-,7+,8+/m0/s1
InChi Key
GKEHVJFBPNPCKI-XLPZGREQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $95

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    10 mg

    $181

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    25 mg

    $428

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    50 mg

    $760

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    Product Description

    5'-Azido-5'-deoxythymidine is a nucleoside derivative and an inhibitor of poly(ADP-ribose) polymerase (PARP; Ki = 12 µM).1 It is also a synthetic intermediate that has been used in the synthesis of antiviral prodrugs.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pivazyan, A.D., Birks, E.M., Wood, T.G., et al. Inhibition of poly(ADP-ribose)polymerase activity by nucleoside analogs of thymidine. Biochem. Pharmacol. 44(5), 947-953 (1992).

    2. Lin, T.-S. Synthesis and in vitro antiviral activity of 3'-O-acyl derivatives of 5'-amino-5'-deoxythymidine: Potential prodrugs for topical application. J. Pharm. Sci. 73(11), 1568-1571 (1984).