An α2-adrenoceptor agonist
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Dexmedetomidine (hydrochloride)

Item No. 15581

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, monohydrochloride
CAS Number
145108-58-3
Molecular Formula
C13H16N2 • HCl
Formula Weight
236.7
Purity
≥99%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
214 nm
SMILES
CC1=C(C)C([C@H](C)C2=CN=CN2)=CC=C1.Cl
InChi Code
InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/m0./s1
InChi Key
VPNGEIHDPSLNMU-MERQFXBCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $96

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    25 mg

    $209

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    50 mg

    $290

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    Product Description

    Dexmedetomidine is the (S)-enantiomer of medetomidine, an imidazole compound that binds to α2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity compared to that of α1-adrenoceptors (Ki = 1.8 μM).1 Dexmedetomidine produces analgesic, sedative, and anxiolytic effects through both presynaptic activation of α2-adrenoceptors, which inhibits norepinephrine release, and postsynaptic activation of α2-adrenoceptors, which inhibits sympathetic activity and decreases blood pressure and heart rate.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Virtanen, R., Savola, J.M., Saano, V., et al. Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist. Eur. J. Pharmacol. 150(1-2), 9-14 (1988).

    2. Gertler, R., Brown, H.C., Mitchell, C.H., et al. Dexmedetomidine: A novel sedative-analgesic agent. Proc. (Bayl. Univ. Med. Cent.) 14(1), 13-21 (2001).

    3. Bajwa, S., and Kulshrestha, A. Dexmedetomidine: An adjuvant making large inroads into clinical practice. Ann. Med. Health Sci. Res. 3(4), 475-483 (2013).

    Product Citations

    Sisco, E., and Appley, M. Identification of the veterinary sedative medetomidine in combination with opioids and xylazine in Maryland. J. Forensic Sci. 68(5), 1708-1712 (2023).