A β2-AR agonist
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Formoterol (hemifumarate hydrate)

Item No. 15584

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
rel-N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-formamide, 2E-butenedioate (2:1), hydrate
Molecular Formula
C19H24N2O4 • 1/2C4H4O4 [XH2O]
Formula Weight
402.5
Purity
≥99%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/mlMethanol: 1 mg/mlWater: Slightly Soluble
λmax
215, 285 nm
SMILES
COC1=CC=C(C[C@H](C)NC[C@@H](O)C2=CC(NC([H])=O)=C(O)C=C2)C=C1.OC(/C=C/C(O)=O)=O.COC3=CC=C(C[C@H](C)NC[C@@H](O)C4=CC(NC([H])=O)=C(O)C=C4)C=C3.O
InChi Code
InChI=1S/2C19H24N2O4.C4H4O4.H2O/c2*1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22;5-3(6)1-2-4(7)8;/h2*3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22);1-2H,(H,5,6)(H,7,8);1H2/b;;2-1+;/t2*13-,19+;;/m00../s1
InChi Key
BPXZSHHCUKRDHD-PGVRECGZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

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    Product Description

    Formoterol is an agonist of the β2-adrenergic receptor (β2-AR).1 It induces cAMP efflux in, and relaxation of, rat tracheal rings precontracted with carbachol (carbamoylcholine; Item No. 14486) when used at a concentration of 1 µM.2 Aerosolized formoterol (10 µg/ml) prevents the late asthmatic response, reduces the number of eosinophils and macrophages in bronchoalveolar lavage fluid (BALF), and reduces bronchial reactivity in a guinea pig model of allergic asthma induced by ovalbumin.3 Formoterol is also an inhibitor of ferroptosis, preventing cell death induced by RSL-3 (Item No. 19288) or erastin (Item No. 17754) in HT-1080 human fibrosarcoma cells in a concentration-dependent manner.4 It scavenges lipid peroxyl radicals in oxidized egg phosphatidylcholine liposomes when used at concentrations ranging from 10 to 100 µM. Formoterol (1 and 5 mg/kg) reduces acute liver injury and hepatic lipid peroxidation induced by acetaminophen (Item No. 10024) in mice. Formulations containing formoterol have been used, alone and in combination with inhaled corticosteroids, in the treatment of chronic obstructive pulmonary disease (COPD) and asthma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Anderson, G.P. Formoterol: Pharmacology, molecular basis of agonism, and mechanism of long duration of a highly potent and selective β2-adrenoceptor agonist bronchodilator. Life Sci. 52(26), 2145-2160 (1993).

    2. Pacini, E.S.A., Sanders-Silveira, S., and Godinho, R.O. The extracellular cAMP-adenosine pathway in airway smooth muscle. J. Pharmacol. Exp. Ther. 366(1), 75-83 (2018).

    3. Sugiyama, H., Okada, C., Bewtra, A.K., et al. The effect of formoterol on the late asthmatic phenomena in guinea pigs. J. Allergy Clin. Immunol. 89(4), 858-866 (1992).

    4. Teng, L.S., Ying, Z.D., Sun, X.H., et al. Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury. Chem. Biol. Interact. 421, 111724 (2025).