A β1- and β2-AR agonist
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Labeled Version(s)
34704Isoproterenol-d7 (hydrochloride)
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Isoproterenol (hydrochloride)

Item No. 15592

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol, monohydrochloride
CAS Number
51-30-9
Synonyms
  • Isoprenaline
  • NSC 37745
  • NSC 89747
Molecular Formula
C11H17NO3 • HCl
Formula Weight
247.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 5mg/ml
λmax
225, 282 nm
SMILES
OC1=C(O)C=C(C(O)CNC(C)C)C=C1.Cl
InChi Code
InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H
InChi Key
IROWCYIEJAOFOW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

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    250 mg

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    500 mg

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    Product Description

    Isoproterenol is an agonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 224 and 458 nM, respectively.1 It is selective for β1- and β2-ARs over β3-ARs (Ki = 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM).2 In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectomized rats.3 It reduces blood pressure and increases heart rate in renal hypertensive rabbits.4 Isoproterenol inhibits histamine-induced bronchospasms in anesthetized dogs.5 Formulations containing isoproterenol have been used in the treatment of bradydysrhythmias and to improve breathing during anesthesia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hoffmann, C., Leitz, M.R., Oberdorf-Maass, S., et al. Comparative pharmacology of human β-adrenergic receptor subtypes—characterization of stably transfected receptors in CHO cells. N.-S. Arch. Pharmacol. 369(2), 151-159 (2004).

    2. Lotti, V.J., Cerino, D., and Kling, P. Characterization of the adrenoreceptor activities of isoprenaline in the field stimulated rat vas deferens: Selective supersensitivity to β2-mediated responses following reserpine treatment. J. Auton. Pharmacol. 2(3), 169-174 (1982).

    3. Hosutt, J.A., Rowland, N., and Stricker, E.M. Hypotension and thirst in rats after isoproterenol treatment. Physiol. Behav. 21(4), 593-598 (1978).

    4. van Boom, M., and Saxena, P.R. Systemic and regional haemodynamic responses to isoprenaline in conscious renal hypertensive rabbits. Clin. Exp. Pharmacol. Physiol. 8(3), 227-239 (1981).

    5. Wasserman, M.A., and Levy, B. Cardiovascular and bronchomotor responses to selective beta adrenergic receptor agonists in the anesthetized dog. J. Pharmacol. Exp. Ther. 189(2), 445-455 (1974).

    Product Citations

    Lahvic, J.L., Ammerman, M., Li, P., et al. Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132. PNAS 115(37), 9252-9257 (2018).