An internal standard for the quantification of isoproterenol
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Unlabeled Version(s)
15592Isoproterenol (hydrochloride)
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Isoproterenol-d7 (hydrochloride)

Item No. 34704

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(1-hydroxy-2-((propan-2-yl-d7)amino)ethyl)benzene-1,2-diol, monohydrochloride
CAS Number
2517584-04-0
Synonyms
  • Isoprenaline-d7
Molecular Formula
C11H10D7NO3 • HCl
Formula Weight
254.8
Purity
≥99% deuterated forms (d1-d7)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
[2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])NCC(C1=CC(O)=C(C=C1)O)O.Cl
InChi Code
InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H/i1D3,2D3,7D;
InChi Key
IROWCYIEJAOFOW-AUYCXRIESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    Product Description

    Isoproterenol-d7 is intended for use as an internal standard for the quantification of isoproterenol (Item No. 15592) by GC- or LC-MS. Isoproterenol is an agonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 224 and 458 nM, respectively).1 It is selective for β1- and β2-ARs over β3-ARs (Ki = 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM).2 In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectomized rats.3 It reduces blood pressure and increases heart rate in renal hypertensive rabbits.4 Isoproterenol inhibits histamine-induced bronchospasms in anesthetized dogs.5 Formulations containing isoproterenol have been used in the treatment of bradydysrhythmias and to improve breathing during anesthesia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hoffmann, C., Leitz, M.R., Oberdorf-Maass, S., et al. Comparative pharmacology of human β-adrenergic receptor subtypes—characterization of stably transfected receptors in CHO cells. N.-S. Arch. Pharmacol. 369(2), 151-159 (2004).

    2. Lotti, V.J., Cerino, D., and Kling, P. Characterization of the adrenoreceptor activities of isoprenaline in the field stimulated rat vas deferens: Selective supersensitivity to β2-mediated responses following reserpine treatment. J. Auton. Pharmacol. 2(3), 169-174 (1982).

    3. Hosutt, J.A., Rowland, N., and Stricker, E.M. Hypotension and thirst in rats after isoproterenol treatment. Physiol. Behav. 21(4), 593-598 (1978).

    4. van Boom, M., and Saxena, P.R. Systemic and regional haemodynamic responses to isoprenaline in conscious renal hypertensive rabbits. Clin. Exp. Pharmacol. Physiol. 8(3), 227-239 (1981).

    5. Wasserman, M.A., and Levy, B. Cardiovascular and bronchomotor responses to selective beta adrenergic receptor agonists in the anesthetized dog. J. Pharmacol. Exp. Ther. 189(2), 445-455 (1974).