A negative control for Src tyrosine kinase inhibitors
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PP3

Item No. 15595

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS Number
5334-30-5
Synonyms
  • NSC 1401
Molecular Formula
C11H9N5
Formula Weight
211.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mLDMSO: 1 mg/mlEthanol: 0.15 mg/ml
λmax
239, 290 nm
SMILES
NC1=C2C=NN(C3=CC=CC=C3)C2=NC=N1
InChi Code
InChI=1S/C11H9N5/c12-10-9-6-15-16(11(9)14-7-13-10)8-4-2-1-3-5-8/h1-7H,(H2,12,13,14)
InChi Key
KKDPIZPUTYIBFX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $63

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    5 mg

    $129

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    10 mg

    $171

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    Product Description

    PP3 is an inactive analog of the Src tyrosine kinase inhibitors PP1 (Item No. 14244) and PP2 (Item No. 13198). At concentrations as high as 10 μM, it does not prevent proliferation mediated by a stem cell factor/mast cell growth factor in hematopoietic and cancer cell lines.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ungefroren, H., Sebens, S., Groth, S., et al. The Src family kinase inhibitors PP2 and PP1 block TGFβ-mediated cellular responses by direct and differential inhibition of type I and type II TGFβreceptors. Curr. Cancer Drug Targets 11(4), 524-535 (2011).

    2. Tatton, L., Morley, G.M., Chopra, R., et al. The Src-selective kinase inhibitor PP1 also inhibits kit and Bcr-Abl tyrosine kinases. The Journal of Biological Chemisty 278(7), 4847-4853 (2003).