A selective serotonin reuptake inhibitor
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Labeled Version(s)
34885Fluvoxamine-d4 (maleate)
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Fluvoxamine (maleate)

Item No. 15617

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone O-(2-aminoethyl)oxime, 2Z-butenedioate
CAS Number
61718-82-9
Synonyms
  • DU-23000
  • MK-264
  • NSC 309469
Molecular Formula
C15H21F3N2O2 • C4H4O4
Formula Weight
434.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
253 nm
SMILES
COCCCC/C(C1=CC=C(C(F)(F)F)C=C1)=N\OCCN.OC(/C=C\C(O)=O)=O
InChi Code
InChI=1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1-
InChi Key
LFMYNZPAVPMEGP-PIDGMYBPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $36

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    25 mg

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    50 mg

    $128

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    100 mg

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    Product Description

    Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI).1 It selectively inhibits reuptake of serotonin over norepinephrine reuptake in rat hypothalamic synaptosomes (Kis = 6.2 and 1,100 nM, respectively). Fluvoxamine (10 mg/kg) reduces immobility time in the forced swim test in mice, an effect that can be blocked by the sigma-1 (σ1) receptor antagonist BD 1047 (Item No. 22928).2 It also reduces marble-burying behavior in the marble-burying test in mice when administered at a dose of 45 mg/kg, indicating anxiolytic- or reduced obsessive compulsive-like behaviors.3 Formulations containing fluvoxamine have been used in the treatment of obsessive compulsive disorder and social anxiety disorder.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Johnson, A.M. An overview of the animal pharmacology of paroxetine. Acta Psychiatr. Scand. 80(Suppl. 350), 14-20 (1989).

    2. Sugimoto, Y., Tagawa, N., Kobayashi, Y., et al. Involvement of the sigma1 receptor in the antidepressant-like effects of fluvoxamine in the forced swimming test in comparison with the effects elicited by paroxetine. Eur. J. Pharmacol. 696(1-3), 96-100 (2012).

    3. Hayashi, A., Yamashita, N., Baba, J., et al. Effects of co-administered fluvoxamine and diazepam, ethyl loflazepate or imipramine on marble-burying behavior in mice. Oyo Yakuri 57(5-6), 103-108 (1999).