A selective antagonist of dopamine D1-like receptors
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SCH 23390 (hydrochloride)

Item No. 15631

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-chloro-2,3,4,5-tetrahydro-3-methyl-5R-phenyl-1H-3-benzazepin-7-ol, monohydrochloride
CAS Number
125941-87-9
Molecular Formula
C17H18ClNO • HCl
Formula Weight
324.2
Purity
≥99%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:7): 0.1 mg/mlEthanol: 5 mg/ml
SMILES
CN1C[C@H](C2=CC=CC=C2)C3=C(C=C(Cl)C(O)=C3)CC1.Cl
InChi Code
InChI=1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
InChi Key
OYCAEWMSOPMASE-XFULWGLBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $156

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    50 mg

    $577

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    Product Description

    SCH 23390 is a halobenzazepine that acts as a selective antagonist of the dopamine D1-like receptor subtypes D1 and D5 (Kis = 0.2 and 0.3 nM, respectively).1 In vivo studies have demonstrated that SCH 23390 can abolish pharmacologically-induced seizures.1 This compound is useful for studying the role of the dopamine system in normal brain function and neurological disorders.2,3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bourne, J.A. SCH 23390: The first selective dopamine D1-like receptor antagonist. CNS Drug Rev. 7(4), 399-414 (2001).

    2. Beninger, R.J., and Miller, R. Dopamine D1-like receptors and reward-related incentive learning. Neurosci. Biobehav. Rev. 22(2), 335-345 (1998).

    3. Oerther, S., and Ahlenius, S. Atypical antipsychotics and dopamine D1 receptor agonism: An in vivo experimental study using core temperature measurements in the rat. J. Pharmacol. Exp. Ther. 292(2), 731-736 (2000).

    4. Patel, S., Rademacher, D.J., and Hillard, C.J. Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity. J. Pharmacol. Exp. Ther. 306(3), 880-888 (2003).

    5. Yang, Z., Asico, L.D., Yu, P., et al. D5 dopamine receptor regulation of phospholipase D. Am. J. Physiol. Heart Circ. Physiol. 288(1), H55-H61 (2005).