For immunochemical detection of MBOAT2
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Alternative(s)
15647MBOAT2 (Internal) Polyclonal Antibody
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MBOAT2 (C-Term) Polyclonal Antibody

Item No. 15646

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Membrane-bound O-Acyltransferase Domain-containing Protein 2
Immunogen
Peptide from the C-terminal region of human MBOAT2
Formulation (Request formulation change)
500 µl of peptide affinity-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol, and 0.02% sodium azide
Host
Rabbit
Applications
FC, IF
Cross Reactivity
(+) MBOAT2
Species Reactivity
(+) Human
UniProt Accession №
Q6ZWT7
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 ea (500 µl)

    $440

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    Product Description

    Membrane-bound O-acyltransferase 2 (MBOAT2) is a membrane-spanning enzyme of the MBOAT family encoded by the LPCAT4 gene in humans.1 It contains multiple transmembrane domains and has two active site residues, an asparagine and a histidine, in common with other MBOAT family members.1 MBOAT2 is expressed in mouse epididymis, brain, testis, and ovary and is localized to the endoplasmic reticulum in CHO cells.2 MBOAT2 has acyltransferase activities, with a preference for using oleoyl-coenzyme A (oleoyl-CoA) as an acyl donor and lysophosphatidylethanolamine (Item No. 25844), lysophosphatidic acid, or lysophosphatidylcholine (Item No. 24331) as acyl acceptors at the sn-2 position.3 MBOAT2 expression is increased in the epithelia of patient-derived pancreatic ductal adenocarcinoma (PDAC) tumor tissue and this expression is inversely correlated with patient survival.4 In contrast, decreased expression of serum circular MBOAT2 RNA levels are found in patients with hypertrophic cardiomyopathy.5 Cayman’s MBOAT2 (C-Term) Polyclonal Antibody can be used for flow cytometry and immunofluorescence applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chang, C.C.Y., Sun, J., and Chang, T.Y. Membrane-bound O-acyltransferases (MBOATs). Front. Biol. 6(3), 177-182 (2011).

    2. Shindou, H., and Shimizu, T. Acyl-CoA:Lysophospholipid acyltransferases. The Journal of Biological Chemisty 284(1), 1-5 (2009).

    3. Gijón, M.A., Riekhof, W.R., Zarini, S., et al. Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. The Journal of Biological Chemisty 283(44), 30235-30245 (2008).

    4. Badea, L., Herlea, V., Dima, S.O., et al. Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia. Hepatogastroenterology 55(88), 2015-2026 (2008).

    5. Sonnenschein, K., Wilczek, A.L., de Gonzalo-Calvo, D., et al. Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy. Sci. Rep. 9(1), 20350 (2019).