Lysophosphatidylethanolamine (egg)

Lysophosphatidylethanolamine (LPE) is a naturally-occurring lysophospholipid that can be generated via deacylation of phosphatidylethanolamine by phospholipase A₂ (PLA₂).^1,2 It increases the phosphorylation of ERK1/2 in PC12 cells, an effect that can be blocked by the MEK inhibitors U-0126 (Item No. 70970) and PD 98059 (Item No. 10006726) and the EGFR inhibitor AG-1478 (Item No. 10010244).¹ LPE also increases neurite outgrowth and expression of neurofilament M in PC12 cells. LPE inhibits the activity of phospholipase D (PLD) partially purified from cabbage.³ This product contains lysophosphatidylethanolamine molecular species with primarily C18:0 and C16:0 fatty acyl chain lengths acylated to the sn-1 position and a hydroxyl group at the sn-2 position.

WARNING This product is not for human or veterinary use.

1. Nishina, A., Kimura, H., Sekiguchi, A., et al. Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK. J. Lipid Res. 47(7), 1434-1443 (2006).

2. Makide, K., Kitamura, H., Sato, Y., et al. Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol. Prostaglandins Other Lipid Mediat. 89(3-4), 135-139 (2009).

3. Ryu, S.B., Karlsson, B.H., Ozgen, M., et al. Inhibition of phospholipase D by lysophosphatidylethanolamine, a lipid-derived senescence retardant. Proc. Natl. Acad. Sci. USA 94(23), 12717-12721 (1997).