For immunochemical detection of GPR41
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FFAR3 (GPR41) (C-Term) Polyclonal Antibody

Item No. 15726

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Free Fatty Acid Receptor 3
  • G Protein-Coupled Receptor 41
Immunogen
peptide from the C-terminal region of human GPR41
Formulation (Request formulation change)
Peptide affinity-purified polyclonal antibody
Storage Buffer
TBS, pH 7.4, with 5 mg/ml BSA when reconstituted in 500 µl deionized water
Host
Rabbit
Applications
FC, IF, and WB
Species Reactivity
(+) Human; other species not tested
UniProt Accession №
O14843
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    GPR41 is a G protein-coupled receptor activated by short chain fatty acids (SCFAs).1,2,3 Several SCFAs have the potential to bind and activate GPR41, with pentanoate being the most potent agonist.2 GPR41 couples through the Pertussis toxin-sensitive Gi/o family and its expression has been described in adipose tissue and the colonic lumen.1,2,3 The activation of GPR41 induces an increase in intracellular Ca2+, ERK1/2 activation, and a decrease in intracellular cAMP.1,2,3 Activation of GPR41 may be involved in intestinal inflammation. The predicted size for GPR41 is 39 kDa. Cayman’s GPR41 (C-term) Polyclonal Antibody detects a 43 kDa band by western blot in cell lysates.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tazoe, H., Otomo, Y., Kaji, I., et al. Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. J. Physiol. Pharmacol. 59(Suppl 2), 251-262 (2008).

    2. Brown, A.J., Goldsworthy, S.M., Barnes, A.A., et al. The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. The Journal of Biological Chemisty 278(13), 11312-13319 (2003).

    3. Le Poul, E., Loison, C., Struyf, S., et al. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. The Journal of Biological Chemisty 278(28), 25481-24591 (2003).