Human Estrogen-Related Receptor, Alpha Reporter Assay System

These nuclear receptor assay systems utilize proprietary human mammalian cells engineered to provide high-level expression of a hybrid form of Human ERRα (also known as NR3B1). Reporter Cells also incorporate a responsive luciferase reporter gene. Quantifying expressed luciferase activity at the assay endpoint provides a sensitive surrogate measure of changes in ERRα activity in treated cells. As is true in vivo, these reporter cells express ERRα in a constitutive state of high-level activity. Therefore, the principle application of this assay system is in the screening of test samples to quantify inverse-agonist activities that they may exert against human ERRα. ERRα Reporter Cells are prepared using INDIGO’s proprietary CryoMite™ process. This cryo-preservation method yields high cell viability post-thaw, and provides the convenience of immediately dispensing healthy, division-competent reporter cells into assay plates. There is no need for intermediate spin-and-wash steps, viability determinations, or cell titer adjustments. [INDIGO Catalog Nos. IB08001-32, IB08001, IB08002]

WARNING This product is not for human or veterinary use.