A skeletal muscle relaxant
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Labeled Version(s)
33377Metaxalone-d6
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Metaxalone

Item No. 15777

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(3,5-dimethylphenoxy)methyl]-2-oxazolidinone
CAS Number
1665-48-1
Synonyms
  • AHR 438
  • NSC 170959
Molecular Formula
C12H15NO3
Formula Weight
221.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/ml
SMILES
CC1=CC(OCC2OC(NC2)=O)=CC(C)=C1
InChi Code
InChI=1S/C12H15NO3/c1-8-3-9(2)5-10(4-8)15-7-11-6-13-12(14)16-11/h3-5,11H,6-7H2,1-2H3,(H,13,14)
InChi Key
IMWZZHHPURKASS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $69

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    25 mg

    $190

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    50 mg

    $317

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    100 mg

    $593

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    Cayman Chemical
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    Product Description

    Metaxalone is a skeletal muscle relaxant.1,2 It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 µM.2 Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 cells. Formulations containing metaxalone have been used in the treatment of lower back pain.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chou, R., Peterson, K., and Helfand, M. Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: A systematic review. J. Pain Symptom Manage. 28(2), 140-175 (2004).

    2. Yamaguchi, M., and Levy, R.M. Metaxalone suppresses production of inflammatory cytokines associated with painful conditions in mouse macrophages RAW264.7 cells in vitro: Synergistic effect with β-caryophyllene. Curr. Mol. Med. 20(8), 643-652 (2020).