An internal standard for the quantification of metaxalone
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Unlabeled Version(s)
15777Metaxalone
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Metaxalone-d6

Item No. 33377

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[3,5-di(methyl-d3)phenoxy]methyl]-2-oxazolidinone
CAS Number
1189944-95-3
Molecular Formula
C12H9D6NO3
Formula Weight
227.3
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble
SMILES
[2H]C([2H])([2H])C1=CC(C([2H])([2H])[2H])=CC(OCC(O2)CNC2=O)=C1
InChi Code
InChI=1S/C12H15NO3/c1-8-3-9(2)5-10(4-8)15-7-11-6-13-12(14)16-11/h3-5,11H,6-7H2,1-2H3,(H,13,14)/i1D3,2D3
InChi Key
IMWZZHHPURKASS-WFGJKAKNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $294

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    Product Description

    Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone (Item No. 15777) by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant.1,2 It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 µM.2 Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 cells. Formulations containing metaxalone have been used in the treatment of lower back pain.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chou, R., Peterson, K., and Helfand, M. Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: A systematic review. J. Pain Symptom Manage. 28(2), 140-175 (2004).

    2. Yamaguchi, M., and Levy, R.M. Metaxalone suppresses production of inflammatory cytokines associated with painful conditions in mouse macrophages RAW264.7 cells in vitro: Synergistic effect with β-caryophyllene. Curr. Mol. Med. 20(8), 643-652 (2020).