An HCN channel blocker
Related Products
Active Metabolite(s)
27808N-desmethyl Ivabradine (hydrochloride)
Labeled Version(s)
25711Ivabradine-d3 (hydrochloride)
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Ivabradine (hydrochloride)

Item No. 15868

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one, monohydrochloride
CAS Number
148849-67-6
Synonyms
  • S 16257
Molecular Formula
C27H36N2O5 • HCl
Formula Weight
505.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
287 nm
SMILES
CN(CCCN1CCC(C=C(OC)C(OC)=C2)=C2CC1=O)C[C@H]3CC4=C3C=C(OC)C(OC)=C4.Cl
InChi Code
InChI=1S/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/m1./s1
InChi Key
HLUKNZUABFFNQS-ZMBIFBSDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $81

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    50 mg

    $297

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    100 mg

    $553

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    250 mg

    $986

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    Product Description

    Ivabradine is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker that blocks the mixed sodium/potassium inward funny current (If) in HEK293 cells expressing mouse HCN1, human HCN2, and human HCN4 (EC50s = 4.5, 4.52, and 4.28 μM, respectively).1 In vivo, ivabradine (10 mg/kg per day) reduces heart rate, incidence of ventricular tachycardia and ventricular fibrillation, and arrhythmic mortality in a rat model of myocardial infarction.2 Formulations containing ivabradine have been used in the treatment of heart failure and angina.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Melchiorre, M., Del Lungo, M., Guandalini, L., et al. Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers. J. Med. Chem. 53(18), 6773-6777 (2010).

    2. Mackiewicz, U., Gerges, J.Y., Chu, S., et al. Ivabradine protects against ventricular arrhythmias in acute myocardial infarction in the rat. J. Cell Physiol. 229(6), 813-823 (2014).