An internal standard for the quantification of ivabradine
Related Products
Unlabeled Version(s)
15868Ivabradine (hydrochloride)
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Ivabradine-d3 (hydrochloride)

Item No. 25711

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl-d3)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one, monohydrochloride
CAS Number
1217809-61-4
Molecular Formula
C27H33D3N2O5 • HCl
Formula Weight
508.1
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
COC(C(OC)=C1)=CC2=C1[C@H](C2)CN(C([2H])([2H])[2H])CCCN3CCC(C=C(OC)C(OC)=C4)=C4CC3=O.Cl
InChi Code
InChI=1S/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/m1./s1/i1D3;
InChi Key
HLUKNZUABFFNQS-AFMQDYKRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $236

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    1 mg

    $445

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    Product Description

    Ivabradine-d3 is intended for use as an internal standard for the quantification of ivabradine (Item No. 15868) by GC- or LC-MS. Ivabradine is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker that blocks the mixed sodium/potassium inward funny current (If) in HEK293 cells expressing mouse HCN1, human HCN2, and human HCN4 (EC50s = 4.5, 4.52, and 4.28 μM, respectively).1 In vivo, ivabradine (10 mg/kg per day) reduces heart rate, incidence of ventricular tachycardia and ventricular fibrillation, and arrhythmic mortality in a rat model of myocardial infarction.2 Formulations containing ivabradine have been used in the treatment of heart failure and angina.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Melchiorre, M., Del Lungo, M., Guandalini, L., et al. Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers. J. Med. Chem. 53(18), 6773-6777 (2010).

    2. Mackiewicz, U., Gerges, J.Y., Chu, S., et al. Ivabradine protects against ventricular arrhythmias in acute myocardial infarction in the rat. J. Cell Physiol. 229(6), 813-823 (2014).