An Analytical Reference Standard
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Alternative(s)
17784Amobarbital
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Amobarbital (sodium salt)

Item No. 15882

Restricted Product (Schedule II)
Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 5-Ethyl-5-isopentylbarbituric Acid
  • NSC 10815
  • NSC 32406
  • NSC 120800
Technical Information
Formal Name
5-ethyl-5-(3-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione, monosodium salt
CAS Number
64-43-7
Molecular Formula
C11H17N2O3 • Na
Formula Weight
248.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.3 mg/mlDMSO: 0.5 mg/mlPBS (pH 7.2): 0.3 mg/ml
λmax
240 nm
SMILES
O=C1C(CCC(C)C)(CC)C(NC(N1)=O)=O.[Na]
InChi Code
InChI=1S/C11H18N2O3.Na/c1-4-11(6-5-7(2)3)8(14)12-10(16)13-9(11)15;/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);
InChi Key
CGIPTVARALDUTG-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
II
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Amobarbital (sodium salt) (Item No. 15882) is an analytical reference standard that is categorized as a barbiturate. By activating GABAA receptors in rat thalamic slices, 100 µM amobarbital elicits a depressant effect, increasing both the amplitude and decay time of inhibitory postsynaptic currents.1 It has also been shown to compete with rotenone (Item No. 13995) for binding at complex I to inhibit mitochondrial electron transport.2 Amobarbital is regulated as a schedule II compound in the United States and intended only for forensic and research purposes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, H.S., Wan, X., Mathers, D.A., et al. Selective GABA-receptor actions of amobarbital on thalamic neurons. Br. J. Pharmacol. 143(4), 485-494 (2004).

    2. Chen, A., Hoppel, C.L., and Lesnefsky, E.J. Blockade of electron transport before cardiac ischemia with the reversible inhibitor amobarbital protects rat heart mitochondria. J. Pharmacol. Exp. Ther. 316(1), 200-207 (2006).