An Analytical Reference Material
Features
  • This product is qualified as a Reference Material that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This product is intended to be used as an analytical reference standard
  • Bulk material is available for academic research at qualified institutions; please contact our sales department for pricing
Related Products
Alternative(s)
15882Amobarbital (sodium salt)
Certified Reference Material(s)
22912Amobarbital (CRM)
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Amobarbital

Item No. 17784

Restricted Product (Schedule II)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 5-Ethyl-5-isopentylbarbituric Acid
  • NSC 10815
  • NSC 32406
  • NSC 120800
Technical Information
Formal Name
5-ethyl-5-(3-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
CAS Number
57-43-2
Molecular Formula
C11H18N2O3
Formula Weight
226.3
Purity
≥98%
Formulation
A neat solid
SMILES
O=C1C(CCC(C)C)(CC)C(NC(N1)=O)=O
InChi Code
InChI=1S/C11H18N2O3/c1-4-11(6-5-7(2)3)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)
InChi Key
VIROVYVQCGLCII-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
II
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Amobarbital (Item No. 17784) is an analytical reference material that is categorized as a barbiturate. By activating GABAA receptors in rat thalamic slices, 100 µM amobarbital elicits a depressant effect, increasing both the amplitude and decay time of inhibitory postsynaptic currents.1 It has also been shown to compete with rotenone (Item No. 13995) for binding at complex I to inhibit mitochondrial electron transport.2 Amobarbital is regulated as a schedule II compound in the United States and intended only for forensic and research purposes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, H.S., Wan, X., Mathers, D.A., et al. Selective GABA-receptor actions of amobarbital on thalamic neurons. Br. J. Pharmacol. 143(4), 485-494 (2004).

    2. Chen, A., Hoppel, C.L., and Lesnefsky, E.J. Blockade of electron transport before cardiac ischemia with the reversible inhibitor amobarbital protects rat heart mitochondria. J. Pharmacol. Exp. Ther. 316(1), 200-207 (2006).