The primary metabolite of doxepin
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Parent Compound(s)
15888Doxepin (hydrochloride)
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Desmethyldoxepin (hydrochloride)

Item No. 15907

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-dibenz[b,e]oxepin-11(6H)-ylidene-N-methyl-1-propanamine, monohydrochloride
CAS Number
2887-91-4
Synonyms
  • Nordoxin
Molecular Formula
C18H19NO • HCl
Formula Weight
301.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 15 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
208, 296 nm
SMILES
CNCC/C=C1C2=C(C=CC=C2)COC3=C/1C=CC=C3.Cl
InChi Code
InChI=1S/C18H19NO.ClH/c1-19-12-6-10-16-15-8-3-2-7-14(15)13-20-18-11-5-4-9-17(16)18;/h2-5,7-11,19H,6,12-13H2,1H3;1H/b16-10-;
InChi Key
GNPPEZGJRSOKRE-HYMQDMCPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

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    10 mg

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    Product Description

    Doxepin (Item No. 15888) is a tricyclic antidepressant. Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver.1,2 The metabolism of tricyclic antidepressants, including doxepin, is affected by a variety of factors, including age, genetics, and drug-drug interactions.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wilson, J.M., Williamson, L.J., and Raisys, V.A. Simultaneous measurement of secondary and tertiary tricyclic antidepressants by GC/MS chemical ionization mass fragmentography. Clin. Chem. 23(6), 1012-1017 (1977).

    2. Rana, S., Uralets, V.P., and Ross, W. A new method for simultaneous determination of cyclic antidepressants and their metabolites in urine using enzymatic hydrolysis and fast GC-MS. J. Anal. Toxicol. 32(5), 355-363 (2008).

    3. Ereshefsky, L., Tran-Johnson, T., Davis, C.M., et al. Pharmacokinetic factors affecting antidepressant drug clearance and clinical effect: Evaluation of doxepin and imipramine—new data and review. Clin. Chem. 34(5), 863-880 (1988).