A major metabolite of the SSRI paroxetine
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Parent Compound(s)
14998Paroxetine (hydrochloride)
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Desmethylene Paroxetine (hydrochloride)

Item No. 15908

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(3S,4R)-4-(4-fluorophenyl)-3-piperidinyl]methoxy]-1,2-benzenediol, monohydrochloride
CAS Number
1394861-12-1
Molecular Formula
C18H20FNO3 • HCl
Formula Weight
353.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
SMILES
FC1=CC=C([C@H]2[C@H](COC3=CC(O)=C(O)C=C3)CNCC2)C=C1.Cl
InChi Code
InChI=1S/C18H20FNO3.ClH/c19-14-3-1-12(2-4-14)16-7-8-20-10-13(16)11-23-15-5-6-17(21)18(22)9-15;/h1-6,9,13,16,20-22H,7-8,10-11H2;1H/t13-,16-;/m0./s1
InChi Key
GIPUDSSHAJOHQK-LINSIKMZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $69

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    10 mg

    $127

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    50 mg

    $363

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    Product Description

    Paroxetine (Item No. 14998) is a potent, selective serotonin reuptake inhibitor (Ki = 0.72 nM) that has been used in cases of depression and anxiety disorder.1,2,3 Desmethylene paroxetine is a major urinary metabolite of paroxetine.4,5 This compound may be used in urine drug testing applications involving paroxetine toxicology or forensic analysis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mattson, R.J., Catt, J.D., Denhart, D.J., et al. Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitors. J. Med. Chem. 48(19), 6023-6034 (2005).

    2. Baldwin, D., Woods, R., Lawson, R., et al. Efficacy of drug treatments for generalised anxiety disorder: Systematic review and meta-analysis. BMJ 342, d1199 (2011).

    3. Ackermann, R.T., and Williams, J.W., Jr. Rational treatment choices for non-major depressions in primary care. J. Gen. Intern. Med. 17(4), 293-301 (2002).

    4. Segura, M., Roura, L., de La Torre, R., et al. Synthesis of the major metabolites of paroxetine. Bioorg. Chem. 31(3), 248-258 (2003).

    5. Wei, P., Kaatz, G.W., and Kerns, R.J. Structural differences between paroxetine and femoxetine responsible for differential inhibition of Staphylococcus aureus efflux pumps. Bioorg. Med. Chem. Lett. 14(12), 3093-3097 (2004).