Paroxetine (hydrochloride)

Paroxetine is a selective serotonin reuptake inhibitor (SSRI; K_i = 0.04 nM).¹ It is selective for the serotonin transporter (SERT) over the dopamine and norepinephrine transporters (K_is = 400 and 90 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT_1A and 5-HT_2A, the histamine H₁ receptor, α₁- and α₂-adrenergic receptors (α₂-ARs), and muscarinic acetylcholine receptors (mAChRs; K_is = 21,168, 6,320, 13,746, 995, 3,915, and 42 nM, respectively).^1,2 Paroxetine (5 mg/kg) decreases immobility time in the forced swim test in mice.³ Formulations containing paroxetine have been used in the treatment of depression, obsessive-compulsive disorder (OCD), panic disorder, social and generalized anxiety disorders, and post-traumatic stress disorder (PTSD).

WARNING This product is not for human or veterinary use.

1. Mattson, R.J., Catt, J.D., Denhart, D.J., et al. Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitors. J. Med. Chem. 48(19), 6023-6034 (2005).

2. Owens, M.J., Neal, W., Plott, S.J., et al. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J. Pharmacol. Exp. Ther. 283(3), 1305-1322 (1997).

3. Sugimoto, Y., Tagawa, N., Kobayashi, Y., et al. Involvement of the sigma1 receptor in the antidepressant-like effects of fluvoxamine in the forced swimming test in comparison with the effects elicited by paroxetine. Eur. J. Pharmacol. 696(1-3), 96-100 (2012).