An inhibitor of protein kinase D
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CID-755673

Item No. 15924

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,4,5-tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one
CAS Number
521937-07-5
Molecular Formula
C12H11NO3
Formula Weight
217.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 0.1 mg/ml
λmax
218, 276, 321 nm
SMILES
OC1=CC2=C(OC3=C2CCCNC3=O)C=C1
InChi Code
InChI=1S/C12H11NO3/c14-7-3-4-10-9(6-7)8-2-1-5-13-12(15)11(8)16-10/h3-4,6,14H,1-2,5H2,(H,13,15)
InChi Key
AACFPJSJOWQNBN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $132

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    10 mg

    $209

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    25 mg

    $458

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    Product Description

    CID-755673 is a small molecule inhibitor of PKD (IC50s = 182, 280, 227 nM for PKD1, 2, and 3, respectively) that exhibits higher selectivity for PKD over Akt, polo-like kinase 1, CDK activating kinase, CAMKII and three different PKC isoforms (IC50s range from 15 to > 50 µM).1 At 25 µM, CID-755673 has been shown to inhibit prostate cancer cell proliferation, cell migration, and invasion.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sharlow, E.R., Giridhar, K.V., LaValle, C.R., et al. Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone. The Journal of Biological Chemisty 283(48), 33516-33526 (2008).