An AChE inhibitor
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Labeled Version(s)
43808Edrophonium-d5 (chloride)
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Edrophonium (chloride)

Item No. 15928

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-ethyl-3-hydroxy-N,N-dimethyl-benzenaminium, monochloride
CAS Number
116-38-1
Molecular Formula
C10H16NO • Cl
Formula Weight
201.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.5 mg/mlDMSO: 2 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
223, 277 nm
SMILES
OC1=CC([N+](C)(C)CC)=CC=C1.[Cl-]
InChi Code
InChI=1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H
InChi Key
BXKDSDJJOVIHMX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $38

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    250 mg

    $66

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    500 mg

    $110

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    1 g

    $183

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    Product Description

    Edrophonium (chloride) is an acetylcholinesterase (AChE) inhibitor that is known to prevent the breakdown of the neurotransmitter acetylcholine by binding specifically to its catalytic site.1 It has been shown to inhibit AChE activity in human red blood cells, purified calf forebrain, and purified octopus brain with Ki values of 0.2, 0.2, and 0.4 µM, respectively.2 Edrophonium is often used as part of a battery of pharmacological tests to confirm a diagnosis of the autoimmune neuromuscular junction disorder, myasthenia gravis.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roufogalis, B.D., and Wickson, V.M. Acetylcholinesterase: Specificity of the peripheral anionic site for cholinergic ligands. Mol. Pharmacol. 11(3), 352-360 (2011).

    2. Boyle, N.A., Talesa, V., Giovannini, E., et al. Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase. J. Med. Chem. 40(19), 3009-3013 (1997).

    3. Juel, V.C., and Massey, J.M. Myasthenia gravis. Orphanet J. Rare Dis. 2, 44 (2007).