An internal standard for the quantification of edrophonium
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Unlabeled Version(s)
15928Edrophonium (chloride)
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Edrophonium-d5 (chloride)

Item No. 43808

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(ethyl-d5)-3-hydroxy-N,N-dimethylbenzenaminium, monochloride
Molecular Formula
C10H11D5NO • Cl
Formula Weight
206.7
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 0.5 mg/mlDMSO: 2 mg/mlEthanol: 10 mg/mlPBS (pH7.2): 10 mg/ml
SMILES
OC1=CC([N+](C)(C)C([2H])([2H])C([2H])([2H])[2H])=CC=C1.[Cl-]
InChi Code
InChI=1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H/i1D3,4D2;
InChi Key
BXKDSDJJOVIHMX-UHBAQTEVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $98

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    5 mg

    $392

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    Product Description

    Edrophonium-d5 (chloride) is intended for use as an internal standard for the quantification of edrophonium (Item No. 15928) by GC- or LC-MS. Edrophonium is an inhibitor of acetylcholinesterase (AChE; Kis = 200, 200, and 400 nM for the human, bovine, and octopus enzymes, respectively).1 It induces repetitive action potentials in voltage-stimulated cat gastrocnemius plantaris muscles when intra-arterially administered at a dose of 10 µg/animal.2 Formulations containing edrophonium have previously been used in tests for diagnosing myasthenia gravis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boyle, N.A., Talesa, V., Giovannini, E., et al. Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase. J. Med. Chem. 40(19), 3009-3013 (1997).

    2. Blaber, L.C., and Bowman, W.C. The effects of some drugs on the repetitive discharges produced in nerve and muscle by anticholinesterases. Int. J. Neuropharmacol. 2(1-2), 1-16 (1963).