A prodrug form of prednisolone
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Active Metabolite(s)
20866Prednisolone
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Prednisolone Phosphate (sodium salt)

Item No. 15933

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11β,17-dihydroxy-21-(phosphonooxy)-pregna-1,4-diene-3,20-dione, disodium salt
CAS Number
125-02-0
Synonyms
  • Disodium Prednisolone 21-Phosphate
  • Prednisolone Sodium Phosphate
Molecular Formula
C21H27O8P • 2Na
Formula Weight
484.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
242 nm
SMILES
O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(COP([O-])([O-])=O)=O)=C1.[Na+].[Na+]
InChi Code
InChI=1S/C21H29O8P.2Na/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-29-30(26,27)28)20(15,2)10-16(23)18(14)19;;/h5,7,9,14-16,18,23,25H,3-4,6,8,10-11H2,1-2H3,(H2,26,27,28);;/q;2*+1/p-2/t14-,15-,16-,18+,19-,20-,21-;;/m0../s1
InChi Key
VJZLQIPZNBPASX-OJJGEMKLSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    Product Description

    Prednisolone phosphate is a prodrug form of the synthetic glucocorticoid prednisolone (Item No. 20866) and a derivative of prednisone (Item No. 20677).1 It is hydrolyzed to prednisolone in vivo. Prednisolone phosphate (10 mg/kg), administered in long-circulating liposomes, decreases inflammation and the levels of IL-1β in the synovium, as well as reduces damage to the cartilage matrix in a mouse model of antigen-induced arthritis.2 It also reduces tumor growth in B16/F10 melanoma and C26 colon carcinoma mouse models when administered in long-circulating liposomes at a dose of 20 mg/kg.3 Formulations containing prednisolone phosphate have been used as anti-inflammatory or immunosuppressive agents.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Frey, B.M., Seeberger, M., and Frey, F.J. Pharmacokinetics of 3 prednisolone prodrugs. Evidence of therapeutic inequivalence in renal transplant patients with rejection. Transplantation 39(3), 270-274 (1985).

    2. Hofkens, W., Storm, G., van den Berg, W.B., et al. Liposomal targeting of glucocorticoids to the inflamed synovium inhibits cartilage matrix destruction during murine antigen-induced arthritis. Int. J. Pharm. 416(2), 486-492 (2011).

    3. Schiffelers, R.M., Metselaar, J.M., Fens, M.H.A.M., et al. Liposome-encapsulated prednisolone phosphate inhibits growth of established tumors in mice. Neoplasia 7(2), 118-127 (2005).