A synthetic glucocorticoid
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Prednisone

Item No. 20677

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
17,21-dihydroxy-pregna-1,4-diene-3,11,20-trione
CAS Number
53-03-2
Synonyms
  • 1,2-Dehydrocortisone
  • NSC 10023
Molecular Formula
C21H26O5
Formula Weight
358.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.1 mg/mlEthanol: 3 mg/ml
λmax
208, 238 nm
SMILES
O=C(CO)[C@@]1(O)CC[C@@]([C@]1(C)C2)([H])[C@@]3([H])[C@]([C@](C=C4)(C)C(CC3)=CC4=O)([H])C2=O
InChi Code
InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
InChi Key
XOFYZVNMUHMLCC-ZPOLXVRWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressant activities.1 It inhibits paw swelling induced by sodium urate in mice by 86% when administered at a dose of 12 mg/kg.2 Prednisone reduces release of IL-6, monocyte chemoattractant protein-2 (MCP-2), MCP-3, RANTES, and TNF-α in stented arteries in a rabbit model of atherosclerosis.3 Formulations containing prednisone have been used in the treatment of non-Hodgkin lymphoma as part of CHOP chemotherapy and as anti-inflammatory or immunosuppressive agents.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brownie, A.C. The metabolism of adrenal cortical steroids. The Adrenal Gland 2, 209-225 (1992).

    2. Fitzgerald, T.J., Williams, B., and Uyeki, E.M. Effects of antimitotic and anti-inflammatory agents on sodium urate-induced paw swelling in mice. Pharmacology 6(5), 265-273 (1971).

    3. Ribichini, F., Joner, M., Ferrero, V., et al. Effects of oral prednisone after stenting in a rabbit model of established atherosclerosis. J. Am. Coll. Cardiol. 50(2), 176-185 (2007).