A cGMP-dependent protein kinase inhibitor
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PKG Inhibitor (trifluoroacetate salt)

Item No. 15995

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginyl-L-lysyl-L-arginyl-L-alanyl-L-arginyl-L-lysyl-L-glutamic acid, trifluoroacetate salt
Synonyms
  • Arginyl-lysyl-arginyl-alanyl-arginyl-lysyl-glutamic acid
  • Protein Kinase G Inhibitor
Molecular Formula
C38H74N18O10 • XCF3COOH
Formula Weight
943.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 15 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)N)=O)CCCCN)=O)CCCNC(N)=N)=O)C)=O)CCCNC(N)=N)=O)CCCCN)N[C@@H](CCC(O)=O)C(O)=O.FC(F)(F)C(O)=O
InChi Code
InChI=1S/C38H74N18O10.C2HF3O2/c1-21(29(59)52-26(13-8-20-50-38(46)47)33(63)54-24(11-3-5-17-40)34(64)56-27(35(65)66)14-15-28(57)58)51-31(61)25(12-7-19-49-37(44)45)55-32(62)23(10-2-4-16-39)53-30(60)22(41)9-6-18-48-36(42)43;3-2(4,5)1(6)7/h21-27H,2-20,39-41H2,1H3,(H,51,61)(H,52,59)(H,53,60)(H,54,63)(H,55,62)(H,56,64)(H,57,58)(H,65,66)(H4,42,43,48)(H4,44,45,49)(H4,46,47,50);(H,6,7)/t21-,22-,23-,24-,25-,26-,27-;/m0./s1
InChi Key
BYYLDYULAYESLO-JZLSJTMMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $289

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    10 mg

    $514

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    Product Description

    PKG inhibitor is a specific cGMP-dependent PKG inhibitor (Ki = 86 µM).1 This synthetic peptide is a nonphosphorylatable analog of a substrate corresponding to the serine-32 phosphorylation site in histone H2B.1 PKG inhibitor has been reported to block cGMP-dependent NMDA potentiation and nitric oxide-induced depression of GABA currents in cultured retinal amacrine cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Glass, D.B. Differential responses of cyclic GMP-dependent and cyclic AMP-dependent protein kinases to synthetic peptide inhibitors. Biochem. J. 213(1), 159-164 (1983).

    2. Wexler, E.M., Stanton, P.K., and Nawy, S. Nitric oxide depresses GABAA receptor function via coactivation of cGMP-dependent kinase and phosphodiesterase. J. Neurosci. 18(7), 2342-2349 (1998).