A pan-RXR antagonist
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UVI3003

Item No. 16026

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[4-hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoic acid
CAS Number
847239-17-2
Molecular Formula
C28H36O4
Formula Weight
436.6
Purity
≥90%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 15 mg/mlEthanol: 20 mg/ml
SMILES
OC1=C(C2=C(OCCCCC)C=C(C(C)(C)CCC3(C)C)C3=C2)C=C(/C=C/C(O)=O)C=C1
InChi Code
InChI=1S/C28H36O4/c1-6-7-8-15-32-25-18-23-22(27(2,3)13-14-28(23,4)5)17-21(25)20-16-19(9-11-24(20)29)10-12-26(30)31/h9-12,16-18,29H,6-8,13-15H2,1-5H3,(H,30,31)/b12-10+
InChi Key
APJSHECCIRQQDV-ZRDIBKRKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

    $193

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    50 mg

    $845

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    Product Description

    UVI3003 is a full antagonist of RXR that demonstrates potent, nanomolar binding affinity.1 At 1 µM, UVI3003 does not affect the corepressor interaction capacity of the RARα subunit in the RAR-RXR heterodimer configuration.1 This compound can be used to isolate the contribution of RXR to the function of RXR heterodimers.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nahoum, V., Pérez, E., Germain, P., et al. Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. Proc. Natl. Acad. Sci. USA 104(44), 17323-17328 (2007).

    2. le Maire, A., Grimaldi, M., Roecklin, D., et al. Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors. EMBO reports 10(4), 367-373 (2009).