A neutral RARα-selective antagonist
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BMS 195614

Item No. 16029

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[[5,6-dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]-benzoic acid
CAS Number
182135-66-6
Synonyms
  • BMS 614
Molecular Formula
C29H24N2O3
Formula Weight
448.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
211, 236, 282 nm
SMILES
CC1(C)C2=CC=C(C(NC3=CC=C(C(O)=O)C=C3)=O)C=C2C(C4=CC(C=CC=C5)=C5N=C4)=CC1
InChi Code
InChI=1S/C29H24N2O3/c1-29(2)14-13-23(21-15-19-5-3-4-6-26(19)30-17-21)24-16-20(9-12-25(24)29)27(32)31-22-10-7-18(8-11-22)28(33)34/h3-13,15-17H,14H2,1-2H3,(H,31,32)(H,33,34)
InChi Key
WGLMBRZXZDAQHP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $152

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    10 mg

    $256

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    25 mg

    $599

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    Product Description

    BMS 195614 is a neutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM).1 It antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR but does not significantly affect nuclear receptor corepressor binding.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Géhin, M., Vivat, V., Wurtz, J.M., et al. Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem. Biol. 6(8), 519-529 (1999).

    2. Germain, P., Gaudon, C., Pogenberg, V., et al. Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists. Chem. Biol. 16(5), 479-489 (2009).