An ester prodrug of PGF2α
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Prostaglandin F2α isopropyl ester

Item No. 16030

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,11α,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid, 1-methylethyl ester
CAS Number
53764-90-2
Synonyms
  • Dinoprost isopropyl ester
  • PGF2α isopropyl ester
Molecular Formula
C23H40O5
Formula Weight
396.6
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS pH 7.2: 50 µg/ml
SMILES
O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1
InChi Code
InChI=1S/C23H40O5/c1-4-5-8-11-18(24)14-15-20-19(21(25)16-22(20)26)12-9-6-7-10-13-23(27)28-17(2)3/h6,9,14-15,17-22,24-26H,4-5,7-8,10-13,16H2,1-3H3/b9-6-,15-14+/t18-,19+,20+,21-,22+/m0/s1
InChi Key
FPABVZYYTCHNMK-YNRDDPJXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    PGF2α isopropyl ester is an ester prodrug of PGF2α with enhanced lipid solubility. Due to better membrane penetration, PGF2α isopropyl ester is more suitable than PGF2α or PGF2α tromethamine salt for topical application in studies on intraocular pressure. The ester functionality is readily hydrolyzed in vivo to release the active compound PGF2α. When administered topically to the eyes of cynomolgus monkeys, a 5 µg dose reduces intraocular pressure by 68% after the fourth day of treatment.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Crawford, K.S., and Kaufman, P.L. Dose-related effects of prostaglandin F2α isopropyl ester on intraocular pressure, refraction, and pupil diameter in monkeys. Invest. Ophthalmol. Vis. Sci. 32(3), 510-519 (1991).