A selective RARβ and RARγ antagonist
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CD2665

Item No. 16031

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[6-[(2-methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl]-benzoic acid
CAS Number
170355-78-9
Molecular Formula
C31H34O5
Formula Weight
486.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 25 mg/ml
λmax
229, 273, 313 nm
SMILES
OC(C1=CC=C(C2=CC(C=C(C34C[C@H]5C[C@H](C[C@@H](C4)C5)C3)C(OCOCCOC)=C6)=C6C=C2)C=C1)=O
InChi Code
InChI=1S/C31H34O5/c1-34-8-9-35-19-36-29-15-26-7-6-25(23-2-4-24(5-3-23)30(32)33)13-27(26)14-28(29)31-16-20-10-21(17-31)12-22(11-20)18-31/h2-7,13-15,20-22H,8-12,16-19H2,1H3,(H,32,33)/t20-,21+,22-,31?
InChi Key
JBALRFFXKQPVLT-BUPRXJOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $235

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    Cayman Chemical
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    Product Description

    CD2665 is a selective retinoic acid receptor (RAR)β and RARγ antagonist (Kds = 110, 306, and > 2,250 nM for RARγ, RARβ, and RARα, respectively, with no binding at RXRα).1 At 10-7 M, it has been used to abrogate retinoic acid (Item No. 11017)-induced antiproliferative and antidifferentiative effects on sebocyte growth.1 This compound has been used in animal and in vitro cell models to explore the role of retinoid signaling in a number of biological processes including memory formation and tumor proliferation.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, M.J., Ciletti, N., Michel, S., et al. The role of specific retinoid receptors in sebocyte growth and differentiation in culture. J. Invest. Dermatol. 114(2), 349-353 (2000).

    2. Alfos, S., Boucheron, C., Pallet, V., et al. A retinoic acid receptor antagonist suppresses brain retinoic acid receptor overexpression and reverses a working memory deficit induced by chronic ethanol consumption in mice. Alcohol. Clin. Exp. Res. 25(10), 1506-1514 (2001).

    3. Marikar, Y., Wang, Z.Q., Duell, E.A., et al. Retinoic acid receptors regulate expression of retinoic acid 4-hydroxylase that specifically inactivates all-trans retinoic acid in human keratinocyte HaCaT cells. J. Invest. Dermatol. 111(3), 434-439 (1998).