Pricing updated 2018-11-19. Prices are subject to change without notice.
Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants.1 Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid (Item No. 90220). Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 µM).2,3,4 It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress.3,4 Jacaric acid is metabolized in vivo to conjugated linoleic acid (Item No. 90140), which is also cytotoxic to cancer cells.5 Jacaric acid inhibits cyclooxygenase-1 in vitro (Ki = 1.7 µM) and, with long term feeding, decreases stearoyl-CoA desaturase expression and activity in mice.6,7
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Miranda, J., Fernández-
Gasmi, J., and Sanderson, J.T. Jacaric acid and its octadecatrienoic acid geoisomers induce apoptosis selectively in cancerous human prostate cells: A mechanistic and 3-
Yamasaki, M., Motonaga, C., Yokoyama, M., et al. Induction of apoptotic cell death in HL-
Liu, W.N., and Leung, K.N. Jacaric acid inhibits the growth of murine macrophage-
Shultz, T.D., Chew, B.P., Seaman, W.R., et al. Inhibitory effect of conjugated dienoic derivatives of linoleic acid and β-
Mashhadi, Z., Boeglin, W.E., and Brash, A.R. Robust inhibitory effects of conjugated linolenic acids on a cyclooxygenase-
Shinohara, N., Ito, J., Tsuduki, T., et al. Jacaric acid, a linolenic acid isomer with a conjugated triene system, reduces stearoyl-