An ω-6 fatty acid
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γ-Linolenic Acid

Item No. 90220

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6Z,9Z,12Z-octadecatrienoic acid
CAS Number
506-26-3
Synonyms
  • FA 18:3
  • GLA
Molecular Formula
C18H30O2
Formula Weight
278.4
Purity
≥98%
Formulation
A 250 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
0.15 M Tris-HCl pH 8.5: >1 mg/mlDMF: >100 mg/mlDMSO: >100 mg/mlEthanol: >100 mg/mlPBS (pH 7.2): <100 µg/ml
SMILES
CCCCC/C=C\C/C=C\C/C=C\CCCCC(=O)O
InChi Code
InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/b7-6-,10-9-,13-12-
InChi Key
VZCCETWTMQHEPK-QNEBEIHSSA-N
Side Chain Carbon Sum
18:3
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $39

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    100 mg

    $74

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    250 mg

    $174

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    1 g

    $328

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    Product Description

    γ-Linolenic acid (GLA) is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins, Leukot. Essent. Fatty Acids 52(5), 293-297 (1995).

    Product Citations

    Zhang, L.J., Salekeen, R., Soto-Palma, C., et al. Article polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells. Cell Press Blue 1(1), 100004 (2026).

    Magtanong, L., Ko, P.-J., To, M., et al. Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state. Cell Chem. Biol. 26(3), 420-432 (2019).

    Yamamoto, T., Matsui, H., Yamaji, K., et al. Narrow-spectrum inhibitors targeting an alternative menaquinone biosynthetic pathway of Helicobacter pylori. J. Infect. Chemother. 22(9), 587-595 (2016).