An allosteric agonist of the CaSR
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Labeled Version(s)
25036Cinacalcet-d3 (hydrochloride)
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Cinacalcet (hydrochloride)

Item No. 16042

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
αR-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine, monohydrochloride
CAS Number
364782-34-3
Synonyms
  • AMG 073
  • KRN 1493
  • Mimpara
Molecular Formula
C22H22F3N • HCl
Formula Weight
393.9
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
λmax
223, 282 nm
SMILES
C[C@@H](NCCCC1=CC(C(F)(F)F)=CC=C1)C2=CC=CC3=C2C=CC=C3.Cl
InChi Code
InChI=1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1
InChi Key
QANQWUQOEJZMLL-PKLMIRHRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    Product Description

    Cinacalcet is a calcimimetic and an allosteric agonist of the calcium-sensing receptor (CaSR; EC50 = 79.4 nM in HEK293T cells expressing the human receptor).1 In vivo, cinacalcet (0.1-10 mg/kg, s.c.) decreases plasma levels of parathyroid hormone (PTH) in rats. It also decreases plasma levels of PTH and parathyroid cell proliferation in a mouse model of primary hyperparathyroidism.2 Formulations containing cinacalcet have been used in the treatment of secondary hyperparathyroidism due to end-stage renal disease and hypercalcemia in patients with parathyroid carcinoma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ma, J.N., Owens, M., Gustafsson, M., et al. Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. J. Pharmacol. Exp. Ther. 337(1), 275-284 (2011).

    2. Imanishi, Y., Kawata, T., Kenko, T., et al. Cinacalcet HCl suppresses Cyclin D1 oncogene-derived parathyroid cell proliferation in a murine model for primary hyperparathyroidism. Calcif. Tissue Int. 89(1), 29-35 (2011).