A NAT10 inhibitor that rescues laminopathies
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Alternative(s)
17346Remodelin
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Remodelin (hydrobromide)

Item No. 16066

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile, monohydrobromide
CAS Number
1622921-15-6
Molecular Formula
C15H14N4S • HBr
Formula Weight
363.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.3 mg/mlEthanol: 0.5 mg/ml
λmax
281 nm
SMILES
N#CC1=CC=C(C2=CSC(N/N=C3CCCC\3)=N2)C=C1.Br
InChi Code
InChI=1S/C15H14N4S.BrH/c16-9-11-5-7-12(8-6-11)14-10-20-15(17-14)19-18-13-3-1-2-4-13;/h5-8,10H,1-4H2,(H,17,19);1H
InChi Key
XNWBCMSPDCSWSD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    Product Description

    Remodelin is a 2-thiazolylhydrazone derivative that, at 10 µM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria.1 Remodelin is an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules.1 Mutation of NAT10 mimics the effects of remodelin on nuclear morphology, suggesting that these effects of remodelin require NAT10.1 Remodelin also has cytotoxic effects against some species of the fungus Candida.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Larrieu, D., Britton, S., Demir, M., et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science 344(6183), 527-532 (2014).

    2. Chimenti, F., Bizzarri, B., Maccioni, E., et al. Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. Bioorg. Med. Chem. Lett. 17(16), 4635-4640 (2007).