Remodelin

Progeria is a genetic disorder that results in the appearance of premature aging. Genetically, progeria is characterized by a mutation in lamin A, which results in misshapen cell nuclei and DNA damage. Remodelin is a 2-thiazolylhydrazone derivative that, at 10 µM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria.¹ Remodelin is an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules.¹ Mutation of NAT10 mimics the effects of remodelin on nuclear morphology, suggesting that these effects of remodelin require NAT10.¹ Remodelin also has cytotoxic effects against some species of the fungus Candida.²

WARNING This product is not for human or veterinary use.

1. Larrieu, D., Britton, S., Demir, M., et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science 344(6183), 527-532 (2014).

2. Chimenti, F., Bizzarri, B., Maccioni, E., et al. Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. Bioorg. Med. Chem. Lett. 17(16), 4635-4640 (2007).

Kanada, F., Takamura, Y., Miyake, S., et al. Histone acetyltransferase and Polo-like kinase 3 inhibitors prevent rat galactose-induced cataract. Sci. Rep. 9(1), 20085 (2019).