A cephalosporin antibiotic
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Cefsulodin (sodium salt hydrate)

Item No. 16127

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(aminocarbonyl)-1-[[(6R,7R)-2-carboxy-8-oxo-7-[[(2R)-2-phenyl-2-sulfoacetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-pyridinium inner salt, monosodium salt, hydrate
CAS Number
1426397-23-0
Molecular Formula
C22H19N4O8S2 • Na [XH2O]
Formula Weight
531.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
265, 352 nm
SMILES
O=C(N[C@@H]1C(N2[C@]1([H])SCC(C[N+]3=CC=C(C(N)=O)C=C3)=C2C([O-])=O)=O)[C@H](S([O-])(=O)=O)C4=CC=CC=C4.[Na+].O
InChi Code
InChI=1S/C22H20N4O8S2.Na.H2O/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12;;/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34);;1H2/q;+1;/p-1/t15-,17-,21-;;/m1../s1
InChi Key
XTRRFIYXAPRYES-NLFZDHTNSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 mg

    $41

    Add

    250 mg

    $95

    Add

    500 mg

    $167

    Add

    1 g

    $255

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Cefsulodin is a cephalosporin antibiotic.1 It is active against 45 isolates of P. aeruginosa (MIC90 = 3.1 µg/ml) and acts synergistically against P. aeruginosa isolates when combined with gentamicin, tobramycin (Item No. 14596), amikacin (Item No. 15405), or mezlocillin (Item No. 30691). Cefsulodin is also active against isolates of S. aureus, S. epidermidis, S. pneumoniae, and S. pyogenes (MIC90s = 8, 8, 12, and 12 µg/ml, respectively). It binds to P. aeruginosa penicillin-binding protein 1a (PBP1a), PBP1b, and PBP3 but not PBP2, PBP4, or PBP5.2 It increases survival in mice infected with various P. aeruginosa strains (ED50s = 1.93-137 mg/kg for all).3 Formulations containing cefsulodin have been used in the treatment of P. aeruginosa infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Neu, H.C., and Scully, B.E. Activity of cefsulodin and other agents against Pseudomonas aeruginosa. Rev. Infect. Dis. 6 (Suppl. 3), S667-S677 (1984).

    2. Noguchi, H., Matsuhashi, M., and Mitsuhashi, S. Comparative studies of penicillin-binding proteins in Pseudomonas aeruginosa and Escherichia coli. Eur. J. Biochem. 100(1), 41-49 (1979).

    3. Kondo, M., and Tsuchiya, K. Comparative in vivo activities of cefsulodin, sulbenicillin, and gentamicin against Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 14(1), 151-153 (1978).