A selective inhibitor of Ces3
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WWL229

Item No. 16182

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3-methoxypropyl)-1-piperidinecarboxylic acid, 4-nitrophenyl ester
CAS Number
1338575-28-2
Molecular Formula
C16H22N2O5
Formula Weight
322.4
Purity
≥98%
Formulation
A 5 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
203, 275 nm
SMILES
O=C(OC1=CC=C([N+]([O-])=O)C=C1)N2CCCCC2CCCOC
InChi Code
InChI=1S/C16H22N2O5/c1-22-12-4-6-13-5-2-3-11-17(13)16(19)23-15-9-7-14(8-10-15)18(20)21/h7-10,13H,2-6,11-12H2,1H3
InChi Key
XVBRVSAGMWRVCK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $120

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    10 mg

    $213

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    25 mg

    $469

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    WWL229 is a selective inhibitor of Ces3 (IC50 = 1.94 µM) that has no significant effect on other, related enzymes.1 By inhibiting the triglyceride hydrolase activity of Ces3, WWL229 promotes lipid storage in cultured adipocytes and prevents basal lipolysis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dominguez, E., Galmozzi, A., Chang, J.W., et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nat. Chem. Biol. 10(2), 113-121 (2014).