An H2S-releasing NSAID
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ATB-346

Item No. 16234

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-methoxy-α-methyl-2-naphthaleneacetic acid, 4-(aminothioxomethyl)phenyl ester
CAS Number
1226895-20-0
Molecular Formula
C21H19NO3S
Formula Weight
365.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
λmax
231 nm
SMILES
COC1=CC=C2C(C=CC(C(C)C(OC3=CC=C(C(N)=S)C=C3)=O)=C2)=C1
InChi Code
InChI=1S/C21H19NO3S/c1-13(21(23)25-18-8-5-14(6-9-18)20(22)26)15-3-4-17-12-19(24-2)10-7-16(17)11-15/h3-13H,1-2H3,(H2,22,26)
InChi Key
YCNMAPLPQYQJFC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $81

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    10 mg

    $145

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    25 mg

    $317

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    50 mg

    $515

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    Product Description

    ATB-346 is a non-steroidal anti-inflammatory drug (NSAID) that releases hydrogen sulfide (H2S) and a derivative of naproxen (Item No. 70290).1 It inhibits the proliferation of, and induces apoptosis in, A375 melanoma cells when used at a concentration of 100 µM.2 ATB-346 decreases prostaglandin E2 (PGE2) production in inflammatory exudates, reduces paw edema, and increases plasma levels of sulfide in a mouse model of zymosan-induced arthritis.1,3 It reduces the size of acetic acid-induced gastric ulcers in mice when administered at a dose of 60 µmol/kg.1 ATB-346 (30 µmol/kg) improves motor function in a mouse model of spinal cord injury.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wallace, J.L., Caliendo, G., Santagada, V., et al. Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346). Br. J. Pharmacol. 159(6), 1236-1246 (2010).

    2. De Cicco, P., Panza, E., Ercolano, G., et al. ATB-346, a novel hydrogen sulfide-releasing anti-inflammatory drug, induces apoptosis of human melanoma cells and inhibits melanoma development in vivo. Pharmacol. Res. 114, 67-73 (2016).

    3. Dief, A.E., Mostafa, D.K., Sharara, G.M., et al. Hydrogen sulfide releasing naproxen offers better anti-inflammatory and chondroprotective effect relative to naproxen in a rat model of zymosan induced arthritis. Eur. Rev. Med. Pharmacol. Sci. 19(8), 1537-1546 (2015).

    4. Campolo, M., Esposito, E., Ahmad, A., et al. A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury. The FASEB Journal 27(11), 4489-1199 (2013).