An NSAID and COX inhibitor
Related Products
Alternative(s)
37554(+)-Naproxen (sodium salt)
Metabolite(s)
34199(S)-O-Desmethyl Naproxen
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

(+)-Naproxen

Item No. 70290

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αS)-6-methoxy-α-methyl-2-naphthaleneacetic acid
CAS Number
22204-53-1
Synonyms
  • CG 3117
  • (S)-Naproxen
Molecular Formula
C14H14O3
Formula Weight
230.3
Purity
≥99%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 24 mg/mlEthanol: 55 mg/mlPBS pH 7.2: 1 mg/ml
λmax
232, 272 nm
SMILES
C[C@H](C(O)=O)C1=CC=C2C=C(OC)C=CC2=C1
InChi Code
InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)
InChi Key
CMWTZPSULFXXJA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 g

    $22

    Add

    5 g

    $50

    Add

    25 g

    $132

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    (+)-Naproxen is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor.1 It inhibits COX-1 and COX-2 in COS-1 cells expressing the human enzymes (IC50s = 4.8 and 28.4 µM, respectively). (+)-Naproxen inhibits thromboxane B2 (TXB2; Item No. 19030) and prostaglandin E2 (PGE2; Item No. 14010) production ex vivo in isolated rat blood (IC50s = 5 and 13 µM, respectively).2 Formulations containing (+)-naproxen have been used in the treatment of arthritis, osteoarthritis, gout, and ankylosing spondylitis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Laneuville, O., Breuer, D.K., DeWitt, D.L., et al. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J. Pharmacol. Exp. Ther. 271(2), 927-934 (1994).

    2. Krekels, E.H.J., Angesjö, M., Sjögren, I., et al. Pharmacokinetic-pharmacodynamic modeling of the inhibitory effects of naproxen on the time-courses of inflammatory pain, fever, and the ex vivo synthesis of TXB2 and PGE2 in rats. Pharm. Res. 28(7), 1561-1576 (2011).