An antagonist of MDM2 action
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JNJ-26854165

Item No. 16259

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1-[2-(1H-indol-3-yl)ethyl]-N4-4-pyridinyl-1,4-benzenediamine
CAS Number
881202-45-5
Synonyms
  • Serdemetan
Molecular Formula
C21H20N4
Formula Weight
328.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:5): 0.1 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/ml
λmax
223, 284 nm
SMILES
C1(NC2=CC=C(NCCC3=CNC4=C3C=CC=C4)C=C2)=CC=NC=C1
InChi Code
InChI=1S/C21H20N4/c1-2-4-21-20(3-1)16(15-24-21)9-14-23-17-5-7-18(8-6-17)25-19-10-12-22-13-11-19/h1-8,10-13,15,23-24H,9,14H2,(H,22,25)
InChi Key
CEGSUKYESLWKJP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    JNJ-26854165 is an antagonist of MDM2 that suppresses the growth of cancer cell lines expressing wild-type p53 (IC50 values range from 240-440 nM).1 It induces p53-mediated transcription culminating in apoptotic death of acute leukemia cells.1 JNJ-26854165 is orally bioavailable and has anti-proliferative as well as apoptotic actions in various tumor models.2 As MDM2 interacts with and modulates several targets in addition to p53, JNJ-26854165 affects multiple signaling pathways.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kojima, K., Burks, J.K., Arts, J., et al. The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias. Mol. Cancer Ther. 9(9), 2545-2557 (2010).

    2. Yuan, Y., Liao, Y.M., Hsueh, C.T., et al. Novel targeted therapeutics: Inhibitors of MDM2, ALK and PARP. J. Hematol. Oncol. 4(16), 1-14 (2011).

    3. Lehman, J.A., Hauck, P.M., Gendron, J.M., et al. Serdemetan antagonizes the Mdm2-HIF1α axis leading to decreased levels of glycolytic enzymes. PLoS One 8(9), 1-5 (2013).

    4. Jones, R.J., Gu, D., Bjorklund, C.C., et al. The novel anticancer agent JNJ-26854165 induces cell death through inhibition of cholesterol transport and degradation of ABCA1. J. Pharmacol. Exp. Ther. 346(3), 381-392 (2013).