A Smo antagonist
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LY2940680

Item No. 16264

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)-benzamide
CAS Number
1258861-20-9
Synonyms
  • Taladegib
Molecular Formula
C26H24F4N6O
Formula Weight
512.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 25 mg/mlEthanol: 10 mg/ml
λmax
220, 320 nm
SMILES
FC1=CC(C(F)(F)F)=C(C(N(C2CCN(C3=C(C=CC=C4)C4=C(C5=CC=NN5C)N=N3)CC2)C)=O)C=C1
InChi Code
InChI=1S/C26H24F4N6O/c1-34(25(37)20-8-7-16(27)15-21(20)26(28,29)30)17-10-13-36(14-11-17)24-19-6-4-3-5-18(19)23(32-33-24)22-9-12-31-35(22)2/h3-9,12,15,17H,10-11,13-14H2,1-2H3
InChi Key
SZBGQDXLNMELTB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $68

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    5 mg

    $179

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    10 mg

    $322

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    Product Description

    LY2940680 is a smoothened (Smo) antagonist.1 It inhibits [35S]GTPγS binding in CHO cells expressing wild-type Smo (IC50 = 294 nM) and reduces production of GLI1 mRNA induced by sonic hedgehog (Shh) in Daoy cells (IC50 = 5.49 nM). Topical application of LY2940680 (2% w/v) decreases skin GLI1 and PTCH1 mRNA expression in depilated mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lauressergues, E., Heusler, P., Lestienne, F., et al. Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model. Pharmacol. Res. Perspect. 4(2), e00214 (2016).