A selective inhibitor of GSK3β
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TDZD-8

Item No. 16287

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione
CAS Number
327036-89-5
Synonyms
  • GSK3β Inhibitor I
  • NP 01139
Molecular Formula
C10H10N2O2S
Formula Weight
222.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
λmax
238 nm
SMILES
O=C1SN(C)C(N1CC2=CC=CC=C2)=O
InChi Code
InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
InChi Key
JDSJDASOXWCHPN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $68

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    10 mg

    $85

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    25 mg

    $116

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    Product Description

    TDZD-8 is a thiadiazolidine derivative that acts as a non-ATP competitive inhibitor of the serine/threonine kinase glycogen synthase kinase 3β (GSK3β; IC50 = 2 µM), binding to the active site of GSK3β.1 It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, cAMP-dependent protein kinase, or protein kinase C (IC50s = >100 µM).1 TDZD-8 has been used to study the role of GSK3β during stem cell differentiation as well as in cell and animal models of Alzheimer’s disease and other neurodegenerative disorders.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Martinez, A., Alonso, M., Castro, A., et al. First non-ATP competitive glycogen synthase kinase 3 β (GSK-3β) inhibitors: Thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer’s disease. J. Med. Chem. 45(6), 1292-1299 (2002).

    2. Guzman, M.L., Li, X., Corbett, C.A., et al. Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8). Blood 110(13), 4436-4444 (2007).

    3. Eldar-Finkelman, H., and Martinez, A. GSK-3 inhibitors: Preclinical and clinical focus on CNS. Front. Mol. Neurosci. 4, 32 (2011).