An immunomodulator
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Y320

Item No. 16314

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide
CAS Number
288250-47-5
Molecular Formula
C27H29ClN6O2
Formula Weight
505.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS(pH 7.2)(1:6): 0.1 mg/ml
λmax
222, 287 nm
SMILES
O=C(C1=C(C)N(C2=CC=C(Cl)C=C2)N=C1)NC(C=C3)=CC(C#N)=C3N(CC4)CCC4N5CCOCC5
InChi Code
InChI=1S/C27H29ClN6O2/c1-19-25(18-30-34(19)24-5-2-21(28)3-6-24)27(35)31-22-4-7-26(20(16-22)17-29)33-10-8-23(9-11-33)32-12-14-36-15-13-32/h2-7,16,18,23H,8-15H2,1H3,(H,31,35)
InChi Key
BWZNJVZTAWBIFG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $145

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    10 mg

    $253

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    25 mg

    $587

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    Product Description

    Y320 is an immunomodulator.1,2 It binds to stimulator of interferon genes (STING; Kd = 202 nM) at an allosteric site and selectively binds to STING over a panel of 468 kinases at 1 µM.2 It inhibits STING signaling induced by the STING agonist MSA-2 (Item No. 30140) in THP-1 cells in a reporter assay (IC50 = 356 nM) to a greater extent than H-151 (Item No. 25857). Y320 also inhibits α2,3- and α2,6-sialylation in PANC-1 pancreatic ductal adenocarcinoma (PDAC) cells (IC50s = 225 and 158 nM, respectively).3 Y320 (25 nM) reduces African swine fever virus (ASFV) replication in porcine alveolar macrophages.4 It inhibits IL-17 release induced by IL-15, chemokine (C-X-C motif) ligand 12 (CXCL12), and an anti-CD3 monoclonal antibody in isolated mouse Th17 and CD4+ T cells (IC50s = 52.4 and 25.7 nM, respectively).1 In vivo, Y320 decreases disease severity in mouse models of collagen-induced arthritis and cisplatin-induced acute kidney injury (AKI).1,2 It decreases tumor volume and increases cytokine secretion by immune cells in the draining lymph nodes in a CT26 murine colon cancer model.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ushio, H., Ishibuchi, S., Oshita, K., et al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel) 7(1), 1-17 (2014).

    2. Chen, Q., Shen, A., Shi, X., et al. Identification of an STING inhibitor targeting the allosteric transmembrane domains. Cell Chem. Biol. 33(5), 623-636 (2026).

    3. Mou, J., Chen, R., Dai, Z., et al. A potent oral sialylation inhibitor augments the immunotherapy in pancreatic ductal adenocarcinoma. ACS Cent. Sci. 11(10), 1969-1983 (2025).

    4. Gao, Q., Xu, Y., Feng, Y., et al. Deoxycholic acid inhibits ASFV replication by inhibiting MAPK signaling pathway. Int. J. Biol. Macromol. 266(Pt 1), 130939 (2024).