An activator of cell death in glioblastoma cells
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Vacquinol-1

Item No. 16321

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-chlorophenyl)-α-2-piperidinyl-4-quinolinemethanol
CAS Number
5428-80-8
Synonyms
  • NSC 13316
Molecular Formula
C21H21ClN2O
Formula Weight
352.9
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 1 mg/mlEthanol: 0.25 mg/ml
λmax
262 nm
SMILES
ClC1=CC=C(C2=NC(C=CC=C3)=C3C(C(O)C4NCCCC4)=C2)C=C1
InChi Code
InChI=1S/C21H21ClN2O/c22-15-10-8-14(9-11-15)20-13-17(16-5-1-2-6-18(16)24-20)21(25)19-7-3-4-12-23-19/h1-2,5-6,8-11,13,19,21,23,25H,3-4,7,12H2
InChi Key
VKLJPGAHSLIQKH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

    $626

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    Cayman Chemical
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    Product Description

    Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells.1 It induces ATP depletion in glioblastoma cells (IC50 = 3.14 µM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells.1 Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics.1 Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kitambi, S.S., Toledo, E.M., Usoskin, D., et al. Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule. Cell 157(2), 313-328 (2014).