Vacquinol-1 (CAS 5428-80-8) | Cayman Chemical
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Vacquinol-1

Item № 16321
CAS № 5428-80-8
Purity ≥98%
product image
                (CAS 5428-80-8)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $45.00 0.00
     5 mg $191.00 0.00
     10 mg $338.00 0.00
     25 mg $731.00 0.00

Pricing updated 2018-12-19. Prices are subject to change without notice.

Description
Synonyms
  • NSC 13316

Vacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture.1 A key effector of vacquinols is MAPK kinase 4 (MKK4).1 Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells.1 It induces ATP depletion in glioblastoma cells (IC50 = 3.14 µM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells.1 Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics.1 Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.1

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Technical Information
Formal Name
2-(4-chlorophenyl)-α-2-piperidinyl-4-quinolinemethanol
CAS Number
5428-80-8
Synonyms
  • NSC 13316
Molecular Formula
C21H21ClN2O
Formula Weight
352.9
Purity
≥98%
Formulation
A crystalline solid
λmax
262 nm
SMILES
ClC1=CC=C(C2=NC(C=CC=C3)=C3C(C(O)C4NCCCC4)=C2)C=C1
InChI Code
InChI=1S/C21H21ClN2O/c22-15-10-8-14(9-11-15)20-13-17(16-5-1-2-6-18(16)24-20)21(25)19-7-3-4-12-23-19/h1-2,5-6,8-11,13,19,21,23,25H,3-4,7,12H2
InChI Key
VKLJPGAHSLIQKH-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Kitambi, S.S., Toledo, E.M., Usoskin, D., et al. Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule Cell 157(2), 313-328 (2014).

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