An ATM kinase inhibitor
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Ku-55933

Item No. 16336

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one
CAS Number
587871-26-9
Synonyms
  • ATM Kinase Inhibitor
Molecular Formula
C21H17NO3S2
Formula Weight
395.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
λmax
246 nm
SMILES
O=C1C=C(C2=C(SC(C=CC=C3)=C3S4)C4=CC=C2)OC(N5CCOCC5)=C1
InChi Code
InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2
InChi Key
XRKYMMUGXMWDAO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $31

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    5 mg

    $70

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    10 mg

    $123

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    25 mg

    $266

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    Product Description

    Ku-55933 is a potent ATP-competitive inhibitor of the ataxia-telangiectasia mutated (ATM) kinase (IC50 = 13 nM; Ki = 2.2 nM).1 Inhibition of ATM by Ku-55933 blocks radiation-induced phosphorylation of downstream cellular targets and sensitizes cells to the cytotoxic effects of both ionizing radiation and chemotherapeutic agents.1 Ku-55933 induces senescent breast, lung, and colon carcinoma cells to undergo cell death.2 It also inhibits HIV-1 replication in C8166 human T-lymophocyte cells with an IC50 value of 2.4 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hickson, I., Zhao, Y., Richardson, C.J., et al. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 64(24), 9152-9159 (2004).

    2. Crescenzi, E., Palumbo, G., de Boer, J., et al. Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: Implications for chemotherapy. Clin. Cancer Res. 14(6), 1877-1887 (2008).

    3. Lau, A., Swinbank, K.M., Ahmed, P.S., et al. Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase. Nat. Cell Biol. 7(5), 493-500 (2005).