An inhibitor of G protein βγ subunit-dependent signaling
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Gallein

Item No. 16344

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3′,4′,5′,6′-tetrahydroxy-spiro[isobenzofuran-1(3H),9′-[9H]xanthen]-3-one
CAS Number
2103-64-2
Synonyms
  • C.I. 45445
  • NSC 56445
  • NSC 8668
  • NSC 622478
  • Pyrogallol phthalein
Molecular Formula
C20H12O7
Formula Weight
364.3
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Slightly soluble
λmax
227 nm
SMILES
OC1=C(O)C2=C(C=C1)C3(C(C=CC=C4)=C4C(O3)=O)C5=CC=C(O)C(O)=C5O2
InChi Code
InChI=1S/C20H12O7/c21-13-7-5-11-17(15(13)23)26-18-12(6-8-14(22)16(18)24)20(11)10-4-2-1-3-9(10)19(25)27-20/h1-8,21-24H
InChi Key
PHLYOKFVXIVOJC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    Product Description

    Gallein is an inhibitor of G protein βγ subunit-dependent signaling.1 It binds to Gβ1γ2 in a cell-free assay (IC50 = 200 nM) and inhibits Gβγ-dependent activation of PI3K in HL-60 cells. Gallein (10 µM) also inhibits Rac1 activation, superoxide production, and chemotaxis induced by N-formyl-Met-Leu-Phe (fMLP; Item No. 21495) in differentiated HL-60 cells. In vivo, gallein (10 mg/kg per day) increases survival, reduces ventricular hypertrophy, and attenuates cardiac remodeling in a mouse model of heart failure induced by transverse aortic constriction (TAC).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lehmann, D.M., Seneviratne, A.M.P.B., and Smrcka, A.V. Small molecule disruption of G protein βγ subunit signaling inhibits neutrophil chemotaxis and inflammation. Mol. Pharmacol. 73(2), 410-418 (2008).

    2. Kamal, F.A., Mickelsen, D.M., Wegman, K.M., et al. Simultaneous adrenal and cardiac G-protein–coupled receptor-Gβγ inhibition halts heart failure progression. J. Am. Coll. Cardiol. 63(23), 2549-2557 (2014).