A selective inhibitor of VEGFR2/FLK1
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SU 1498

Item No. 16354

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-2-propenamide
CAS Number
168835-82-3
Synonyms
  • AG-1498
  • Tyrphostin SU 1498
Molecular Formula
C25H30N2O2
Formula Weight
390.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/ml
λmax
249, 348, 356 nm
SMILES
O=C(/C(C#N)=C/C1=CC(C(C)C)=C(O)C(C(C)C)=C1)NCCCC2=CC=CC=C2
InChi Code
InChI=1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+
InChi Key
JANPYFTYAGTSIN-FYJGNVAPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $38

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    1 mg

    $71

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    5 mg

    $129

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    Product Description

    SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1,2 It effectively blocks signaling through VEGFR2 both in vitro and in vivo.1,3 SU 1498 is used to study the role of VEGFR2 signaling in diverse processes, including angiogenesis, tumor growth, neural progenitor cell survival, and neuroregeneration.3,4,5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Strawn, L.M., McMahon, G., App, H., et al. Flk-1 as a target for tumor growth inhibition. Cancer Res. 56(15), 3540-3545 (1996).

    2. Fedorov, O., Marsden, B., Pogacic, V., et al. A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc. Natl. Acad. Sci. USA 104(51), 20523-20528 (2007).

    3. Arbiser, J.L., Larsson, H., Claesson-Welsh, L., et al. Overexpression of VEGF 121 in immortalized endothelial cells causes conversion to slowly growing angiosarcoma and high level expression of the VEGF receptors VEGFR-1 and VEGFR-2 in vivo. Am. J. Pathol. 156(4), 1469-1476 (2000).

    4. Francescone, R., Scully, S., Bentley, B., et al. Glioblastoma-derived tumor cells induce vasculogenic mimicry through Flk-1 protein activation. The Journal of Biological Chemisty 287(29), 24821-24831 (2012).

    5. Harms, K.M., Li, L., and Cunningam, L.A. Murine neural stem/progenitor cells protect neurons against ischemia by HIF-1α-regulated VEGF signaling. PLoS One 5(3), 1-12 (2010).

    6. Pan, Z., Fukuoka, S., Karagianni, N., et al. Vascular endothelial growth factor promotes anatomical and functional recovery of injured peripheral nerves in the avascular cornea. FEBS J. 27(7), 2756-2767 (2013).