A reduced form of α-lipoic acid
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Dihydrolipoic Acid

Item No. 16372

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,8-dimercapto-octanoic acid
CAS Number
462-20-4
Synonyms
  • DHLA
Molecular Formula
C8H16O2S2
Formula Weight
208.3
Purity
≥95%
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:8): 0.25 mg/ml
SMILES
OC(CCCCC(S)CCS)=O
InChi Code
InChI=1S/C8H16O2S2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H,9,10)
InChi Key
IZFHEQBZOYJLPK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $36

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    50 mg

    $63

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    100 mg

    $96

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    500 mg

    $336

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    Cayman Chemical
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    Product Description

    Dihydrolipoic acid (DHLA) is a dithiol-containing carboxylic acid that is the reduced form of α-lipoic acid (Item No. 10005728). It acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species, including hydroxyl radicals, peroxynitirite, hydrogen peroxide, and hypochlorite, at concentrations ranging from 0.01-0.5 mM.1 At concentrations of 50-100 µM, DHLA triggers apoptosis of mouse embryonic stem cells and human cancer cells, suppressing proliferation.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moini, H., Packer, L., and Saris, N.E.L. Antioxidant and prooxidant activities of α-lipoic acid and dihydrolipoic acid. Toxicol. Appl. Pharmacol. 182(1), 84-90 (2002).

    2. Houng, W.L., Lin, C.A.J., Shen, J.L., et al. Dihydrolipoic acid induces cytotoxicity in mouse blastocysts through apoptosis processes. Int. J. Mol. Sci. 13(3), 3988-4002 (2012).